GreenTea&Mold

Green Tea & Mold

This page contains educational material about Chronic Inflammatory Response Syndrome due to water damaged building (CIRS). This is a biotoxin illness is that is caused by mold. Other biotoxin illnesses have similar signs and symptoms. They are also treated similarly. Some of them are discussed on this site. This information is for educational purposes only. Nothing in this text is intended to serve as medical advice. All medical decisions should be made only with the guidance of your own personal medical authority. I am doing my best to get this data up quickly and correctly. If you find errors in this data, please let me know.

Biotoxin/Mold

Green Tea polyphenols protective against aflatoxin B1: Will reduce level by 15% in three months when taking 500 mg BID. Equivalent to two cups of strong green tea.
Carcinogenesis. 2008 Feb;29(2):411-7. doi: 10.1093/carcin/bgn008. Epub 2008 Jan 12.
Modulation of aflatoxin biomarkers in human blood and urine by green tea polyphenols intervention.
Tang L1, Tang M, Xu L, Luo H, Huang T, Yu J, Zhang L, Gao W, Cox SB, Wang JS.
PMID: 18192689 [PubMed - indexed for MEDLINE] Free full text

My review of this article: There is an association between hepatitis B, aflatoxin exposure and hepatocellular carcinoma. This is one of the most common cancers in SE Asia and W. Africa. Green tea polyphenols(GTP) have been found to inhibit a variety of carcinogenic tumors, inclduing aflatoxin induced liver tumors. Several studies observed that GTPs modulated AFB1 metabolism, inhibited AFB1 DNA binding and AFB1-induced glutathione S-transferase (GST)-positive hepatocytes (Qin G, et al. 1997)

aflatoxins are primarily produced by Aspergilus flavus and Aspergilus parasiticus and are contaminants in the food supply. Aflatoxin B1(AFB1) is hepatotoxic and genotoxic and a known human carcinogen. Chronic expospure to low levels is known to be a risk for HCC. Vaccination for hepatitis B and food safety controls are being attempted but in the mean time researchers are looking for another method to prevent HCC. Ingestion of GTP on a daily basis is a method they are examining.

This research examined the use of green tea polyphenols in human subjects by looking at aflatoxin biomarkers in individuals at high risk of hepatocullular carcinoma(HCC). The same researchers looked at aflatoxin damage by examining the biomarkers of oxidative DNA damage in a prior experiment undertaken for 3 months and found green tea polyphenols reduced these biomarkers. This research was undertaken to further evaluate the aflatoxin biomarkers in the serum and urine samples of the subjects.

116 subjects completed the 3 months trial. They all had detectable aflatoxin marker in their serum. All three treatment groups had similar levels at the start of the trial. The placebo group never changed. The group given 500 mgs per day of green tea polyphenols had a significant decrease and the group given 1000mg had a marginally significant decrease.

The subjects urine samples had similar amounts of aflatoxin marker in them at the beginning of the study. The placebo group did not change while the 500mg polyphenol group had a reduction of 42% and the 1000mg plyphenol group had a reduction of 43%. at 3 months.

Inhibitory effects of tea extract on aflatoxin production by Aspergillus flavus.
Mo HZ, Zhang H, Wu QH, Hu LB.
Lett Appl Microbiol. 2013 Jun;56(6):462-6. doi: 10.1111/lam.12073. Epub 2013 Apr 22.
PMID: 23573983 [PubMed - indexed for MEDLINE]

Modulation of aflatoxin biomarkers in human blood and urine by green tea polyphenols intervention.
Tang L, Tang M, Xu L, Luo H, Huang T, Yu J, Zhang L, Gao W, Cox SB, Wang JS.
Carcinogenesis. 2008 Feb;29(2):411-7. doi: 10.1093/carcin/bgn008. Epub 2008 Jan 12.
PMID: 18192689 [PubMed - indexed for MEDLINE] Free Article

A comparative study on the antimutagenic properties of aqueous extracts of Aspalathus linearis (rooibos), different Cyclopia spp. (honeybush) and Camellia sinensis teas.
van der Merwe JD, Joubert E, Richards ES, Manley M, Snijman PW, Marnewick JL, Gelderblom WC.
Mutat Res. 2006 Dec 10;611(1-2):42-53. Epub 2006 Sep 1.
PMID: 16949333 [PubMed - indexed for MEDLINE]

Inhibition of eleven mutagens by various tea extracts, (-)epigallocatechin-3-gallate, gallic acid and caffeine.
Hour TC, Liang YC, Chu IS, Lin JK.
Food Chem Toxicol. 1999 Jun;37(6):569-79.
PMID: 10478825 [PubMed - indexed for MEDLINE]

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Biotoxin/Mold